Blar i Brage NIH på forfatter "Sharples, Adam"

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    • Aging, Skeletal Muscle, and Epigenetics 

      Stewart, Claire E.; Sharples, Adam (Peer reviewed; Journal article, 2022)
      We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion by 2030 and 2.1 billion by 2050 (WHO). In the USA, ...

    • DNA methylation across the genome in aged human skeletal muscle tissue and muscle‑derived cells: The role of HOX genes and physical activity 

      Turner, Daniel C.; Gorski, Piotr Patryk; Massar, Mohd Firdaus; Seaborne, Robert A.; Baumert, Phillipp; Brown, Alexander D.; Erskine, Robert M.; Dos-Remedios, Ian; Voisin, Sarah; Eynon, Nir; Borisov, Oleg; Larin, Andrey; Semenova, Ekaterina A.; Popov, Daniil; Drust, Barry; Owens, Daniel J.; Ahmetov, Ildus I.; Sharples, Adam; Kitchen, Mark O.; Sultanov, R. I.; Generozov, Edward V.; Stewart, Claire E. (Peer reviewed; Journal article, 2020)
      Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue ...

    • An epigenetic clock for human skeletal muscle 

      Voisin, Sarah; Harvey, Nicholas R; Haupt, Larisa M; Griffiths, Lyn R; Aston, Kevin J; Coffey, Vernon G.; Doering, Thomas M; Thompson, Jamie-Lee M; Benedict, Christian; Cedernaes, Jonathan; Lindholm, Malene E; Craig, Jeffrey M; Rowlands, David S; Sharples, Adam; Horvath, Steve; Eynon, Nir (Peer reviewed; Journal article, 2020)
      Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ...

    • Graded reductions in pre-exercise glycogen concentration do not augment exercise-induced nuclear AMPK and PGC-1α protein content in human muscle 

      Hearris, Mark A.; Owens, Daniel J.; Strauss, Juliette A.; Shepherd, Sam O.; Sharples, Adam; Morton, James P.; Louis, Julien (Peer reviewed; Journal article, 2020)
      We examined the effects of graded muscle glycogen on the subcellular location and protein content of AMP‐activated protein kinase (AMPK) and peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) and mRNA ...

    • Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism 

      Hughes, David C.; Turner, Daniel C.; Baehr, Leslie M.; Seaborne, Robert A.; Viggars, Mark; Jarvis, Jonathan C.; Gorski, Piotr Patryk; Stewart, Claire E.; Owens, Daniel J.; Bodine, Sue C.; Sharples, Adam (Peer reviewed; Journal article, 2020)
      UBR5 is an E3-ubiquitin-ligase positively associated with anabolism, hypertrophy and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle mass remains ...

    • Mimicking exercise in vitro - effects of myotube contractions and mechanical stretch on omics 

      Lautaoja, Juulia H; Turner, Daniel; Sharples, Adam; Kivelä, Riikka; Pekkal, Satu; Hulmi, Juha J; Ylä-Outinen, Laura (Peer reviewed; Journal article, 2023)
      The number of studies using skeletal muscle (SkM) cell culture models to study exercise in vitro are rapidly expanding. Progressively, more comprehensive analysis methods, such as different omics approaches including ...

    • Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training 

      Egan, Brendan; Sharples, Adam (Peer reviewed; Journal article, 2022)
      Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured exercise training is a potent stimulus for physiological adaptation in many organs. Specifically in skeletal muscle, remarkable ...

    • PGC-1α alternative promoter (Exon 1b) controls augmentation of total PGC-1α gene expression in response to cold water immersion and low glycogen availability 

      Allan, Robert; Morton, James P.; Close, Graeme L.; Drust, Barry; Gregson, Warren; Sharples, Adam (Peer reviewed; Journal article, 2020)
      This investigation sought to determine whether post-exercise cold water immersion and low glycogen availability, separately and in combination, would preferentially activate either the Exon 1a or Exon 1b Peroxisome ...

    • Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle 

      Ruple, Bradley A; Godwin, Joshua S.; Mesquita, Paulo H. C; Osburn, Shelby C; Vann, Christopher G; Lamb, Donald A; Sexton, Casey L; Candow, Darren G; Forbes, Scott C; Frugé, Andrew D.; Kavazis, Andreas N; Young, Kaelin C; Seaborne, Robert A.; Sharples, Adam; Roberts, Michael D (Peer reviewed; Journal article, 2021)
      Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ...

    • Ubiquitin ligases in longevity and aging skeletal muscle 

      Hughes, David C.; Baehr, Leslie M.; Waddell, David S.; Sharples, Adam; Bodine, Sue C. (Peer reviewed; Journal article, 2022)
      The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome ...